6/18/2023 0 Comments Mucomyst antidote![]() ![]() In the treatment of paracetamol (acetaminophen) overdose, acetylcysteine acts to maintain or replenish depleted glutathione reserves in the liver and enhance non-toxic metabolism of acetaminophen. ![]() This may lead to severe liver damage and even death by acute liver failure. This metabolite is then free to react with key hepatic enzymes, thereby damaging liver cells. It is normally conjugated by glutathione, but when taken in excess, the body's glutathione reserves are not sufficient to deactivate the toxic NAPQI. When paracetamol is taken in large quantities, a minor metabolite called N-acetyl- p-benzoquinone imine ( NAPQI) accumulates within the body. ![]() Intravenous and oral formulations of acetylcysteine are available for the treatment of paracetamol (acetaminophen) overdose. The sulfur-containing amino acids cysteine and methionine are more easily oxidized than the other amino acids. It is on the World Health Organization's List of Essential Medicines. Īcetylcysteine was initially patented in 1960 and came into medical use in 1968. When inhaled, it acts as a mucolytic by decreasing the thickness of mucus. For paracetamol overdose, it works by increasing the level of glutathione, an antioxidant that can neutralise the toxic breakdown products of paracetamol. A non-immune type of anaphylaxis may also occur. The skin may occasionally become red and itchy with any route of administration. Ĭommon side effects include nausea and vomiting when taken by mouth. Some people use it as a dietary supplement. ![]() It can be taken intravenously, by mouth, or inhaled as a mist. It has been used to treat lactobezoar in infants. Acetylcysteine, also known as N-acetylcysteine ( NAC), is a medication that is used to treat paracetamol overdose and to loosen thick mucus in individuals with chronic bronchopulmonary disorders like pneumonia and bronchitis. ![]()
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